Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8535027 | Life Sciences | 2018 | 38 Pages |
Abstract
Offspring from fructose-fed dams showed reduced StAR and P450(17α) mRNA levels, along with decreased protein expression levels. Conversely, attenuated P450arom protein level was found in the absence of mRNA expression alteration. Consistent with these phenomena, decreased circulating levels of estradiol were observed. Furthermore, estrogen receptor α (ERα) protein levels were also down-regulated. In accordance, the mRNA for progesterone receptor, a transcriptional target of ERα, was decreased. These results suggest that maternal fructose might alter ovarian physiology in the subsequent generation.
Keywords
3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomeraseDevelopmental origins of health and disease (DOHaD)DOHaDPGRP450sccERα3β-HSD17β-estradiolEstradiolER stressEndoplasmic reticulum stressEstrogenOvaryDevelopmental origins of health and diseaseStarFructoseSteroidogenic acute regulatory proteinEstrogen receptor αProgesterone receptor
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Authors
Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Takeru Ota, Yuji Hattori, Nao Sadamoto, Koji Suzuki, Hiroaki Ishikawa, Shuji Hashimoto, Koji Ohashi,