Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8535136 | Life Sciences | 2018 | 7 Pages |
Abstract
The present study provides a novel approach for klotho gene therapy and demonstrates that direct up-regulation of klotho in the brain might improve aging-related memory impairments and decrease oxidative stress. The underlying mechanism of this effect likely involves the inhibition of the Akt/FoxO1 pathway.
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Authors
Hong-Jing Zhou, Chen-Ye Zeng, Ting-Ting Yang, Fang-Yi Long, Xi Kuang, Jun-Rong Du,