Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells

Article ID	Journal	Published Year	Pages	File Type
8535706	Life Sciences	2018	29 Pages	PDF

Abstract

Overall, these results demonstrate that curcumin-induced mild ER stress increases osteoblast differentiation via ATF6 expression in C3H10T1/2 cells.

Keywords

NF-κB OSE2 IRE-1 CREBH BMP2 UPR AP-1 RANKL RUNX2 ATF EDEM DMEM PBS FBS BiP Dulbecco's modified Eagle Medium MTT PKR-like endoplasmic reticulum kinase ALP Alkaline phosphatase STAT inositol-requiring enzyme 1 Osteocalcin Osteoblast differentiation CHOP fetal bovine serum endoplasmic reticulum Runt-related transcription factor 2 nuclear factor-κB activated protein-1 activating transcription factor Signal transducer and activator of transcription Phosphate-buffered saline BMP Unfolded protein response Immunoglobulin binding protein Bone morphogenetic protein PERK Curcumin

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Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells

Authors

Hyo-Eun Son, Eun-Jung Kim, Won-Gu Jang,