Article ID Journal Published Year Pages File Type
8535883 Life Sciences 2018 33 Pages PDF
Abstract
The major finding of the present study is that the PI-3-K/Akt and the MAPK/ERK signaling pathways appear to be constitutively active in the piglet brain, and this activation remains unaltered during HIE development. Thus, neuroprotective strategies aiming to activate these pathways to limit apoptotic neuronal death may offer limited efficacy in this translational model.
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Authors
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