Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8535883 | Life Sciences | 2018 | 33 Pages |
Abstract
The major finding of the present study is that the PI-3-K/Akt and the MAPK/ERK signaling pathways appear to be constitutively active in the piglet brain, and this activation remains unaltered during HIE development. Thus, neuroprotective strategies aiming to activate these pathways to limit apoptotic neuronal death may offer limited efficacy in this translational model.
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Authors
Viktória Kovács, Valéria Tóth-Szűki, János Németh, Viktória Varga, Gábor RemzsÅ, Ferenc Domoki,