| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8535941 | Life Sciences | 2018 | 9 Pages |
Abstract
These studies provide additional confirmation for the mixed μ/δ activity of M6S and demonstrate potential improved clinical utility for dual μ/δ agonists relative to morphine in treatment of diabetic neuropathy across multiple pain domains.
Keywords
PPTPainful diabetic polyneuropathyPDPNOIHNLDEmaxDPNNTXED50STZMPETFLPSThptDiabetic polyneuropathypaw pressure thresholdstreptozotocinSprague DawleyMaximum possible effectPainStreptozotocin-induced diabetestail flick latencyAntinociceptionmorphineNor-BNINaltrexone hydrochlorideOpioid-induced hyperalgesiakappa opioid receptordelta-opioid receptorOpioid receptorsmu-opioid receptor
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Authors
Jai Shankar K. Yadlapalli, Navdeep Dogra, Anqi W. Walbaum, Paul L. Prather, Peter A. Crooks, Maxim Dobretsov,