| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8535947 | Life Sciences | 2018 | 6 Pages |
Abstract
The COX enzymes, especially COX-2, play an important role in the contraction of pregnant uteri in rat. Tocopherol has a tissue specific COX-2 activity increasing effect in pregnant rat uterus but has no such action in non-pregnant uteri or tracheal tissue. Hereby, tocopherol may intensify selectively the uterine relaxing effect of COX-2 inhibitors in preterm contractions. However, tocopherol can enhance the contractile response of pregnant uterus that may increase the risk of premature contractions.
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Authors
Anna Kothencz, Judit Hajagos-Tóth, Adrienn Csányi, Róbert Gáspár,