Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8537268 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2018 | 20 Pages |
Abstract
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic spines correlate with the functional changes in excitatory synapses and are heavily dependent on the remodeling of the underlying actin cytoskeleton. Recent evidence implicates synapses at dendritic spines as important substrates of pathogenesis in neuropsychiatric disorders, including autism spectrum disorder (ASD). Although synaptic perturbations are not the only alterations relevant for these diseases, understanding the molecular underpinnings of the spine and synapse pathology may provide insight into their etiologies and could reveal new drug targets. In this review, we will discuss recent findings of defective actin regulation in dendritic spines associated with ASD.
Keywords
mTORC1ANKSH3LKSgrafRho GTPasesGEFACTN4LGDGSNSyngap1PAKATF3mEPSCDMDmGluRFXSFMRPSRA1WAVE regulatory complexDiffuse B-cell lymphomaCopy-number variantsspectrin repeatsPostsynapseα-Actinin-4SAPAPcalcium-calmodulin kinase IIPI3KADNPABI-1TADAABP1myosin IXBMYO9BCYFIP1WRCADFCNVFDRPSDFRAPSAMmTORTSCCaMKIIRac1DISC1NMJNMDGTPase Activating ProteinMAPKmTOR complex 1NeuroliginAnkyrinNeuromuscular junctionAutism spectrum disorderStriatinBARADHDpostsynaptic densitylong-term potentiationLTPminiature excitatory postsynaptic currentsCNSDBLDystrophinActin dynamicsembryonic dayRas-related C3 botulinum toxin substrate 1dendritic spinesfragile X syndromeLandau-Kleffner syndromecentral nervous systemShank3GAPactin-depolymerizing factornonsense-mediated mRNA decayPhosphatidylinositol 3-kinaseZincfluorescence recovery after photobleachingsterile alpha motiffalse discovery rateASDmammalian target of rapamycinDbl homologySrc homology 3Pleckstrin Homologycalponin homologysynaptic vesiclefragile X mental retardation proteinActivity-dependent neuroprotective proteinGelsolinAttention deficit/hyperactivity disorderTuberous sclerosis complexp21-activated kinasemitogen-activated protein kinasesMetabotropic glutamate receptorsRock
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Authors
Merja Joensuu, Vanessa Lanoue, Pirta Hotulainen,