Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8538214 | Toxicology and Applied Pharmacology | 2018 | 12 Pages |
Abstract
We propose to incorporate mechanistic knowledge and data derived from in vitro studies to support various regulatory applications including: (a) the identification of potential DNT triggers, (b) initial chemical screening and prioritization, (c) hazard identification and characterization, (d) chemical biological grouping, and (e) assessment of exposure to chemical mixtures. Ideally, currently available cellular neuronal/glial models derived from human induced pluripotent stem cells (hiPSCs) should be used as they allow evaluation of chemical impacts on key neurodevelopmental processes, by reproducing different windows of exposure during human brain development. A battery of DNT in vitro test methods derived from hiPSCs could generate valuable mechanistic data, speeding up the evaluation of thousands of compounds present in industrial, agricultural and consumer products that lack safety data on DNT potential.
Keywords
Related Topics
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Health, Toxicology and Mutagenesis
Authors
Anna Bal-Price, Francesca Pistollato, Magdalini Sachana, Stephanie K. Bopp, Sharon Munn, Andrew Worth,