Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation

Article ID	Journal	Published Year	Pages	File Type
8538503	Toxicology and Applied Pharmacology	2018	49 Pages	PDF

Keywords

IgE PKC DNP CCCP CRAC FCCP MPTP IP3 SOCE ToM RBL TCS FPALM RBL-2H3 PMP NIH-3T3 MMP 2,4-Dinitrophenol AUC BSA Ca2+Inositol 1,4,5-triphosphate ROS Adenosine Triphosphate ATP bovine serum albumin translocase of the outer membrane mitochondrial permeability transition pore Immunoglobulin E Triclosan standard error of the mean endoplasmic reticulum Degranulation SERCA Mast cell SEM area under the curve Mitochondria Microtubules Super-resolution microscopy Store-operated calcium entry Antigen Membrane potential Plasma membrane potential Mitochondrial membrane potential Protein kinase C Keratinocyte Carbonyl cyanide 3-chlorophenylhydrazone carbonyl cyanide-p-trifluoromethoxyphenylhydrazone Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Preview

Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation

Authors

Lisa M. Weatherly, Andrew J. Nelson, Juyoung Shim, Abigail M. Riitano, Erik D. Gerson, Andrew J. Hart, Jaime de Juan-Sanz, Timothy A. Ryan, Roger Sher, Samuel T. Hess, Julie A. Gosse,