| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8538544 | Toxicology and Applied Pharmacology | 2018 | 36 Pages |
Abstract
The results suggest that the higher DOX concentration mainly induces p53-dependent apoptosis, whereas for the lower DOX concentration the cardiotoxic effects involve bioenergetic failure, unveiling PDH as a possible therapeutic target to decrease DOX cardiotoxicity.
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Authors
Teresa Cunha-Oliveira, Luciana L. Ferreira, Ana Raquel Coelho, Cláudia M. Deus, Paulo J. Oliveira,