Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose?

Article ID	Journal	Published Year	Pages	File Type
8539176	Toxicology and Applied Pharmacology	2016	12 Pages	PDF

Keywords

DOPAC MLD DZP 5-HIAA MRT MAO PrP tmax MOR LD50 T1/2β Cmax BZD 3,4-dihydroxyphenylacetic acid 5-Hydroxyindoleacetic acid 50% lethal dose AUC LC-HRMS γ-aminobutyric acid Electroencephalogram peak concentration benzodiazepine Tramadol seizure Volume of distribution Minute volume Tidal volume intraperitoneal CNS Respiratory depression diazepam inspiratory time subcutaneous Serotonin central nervous system respiratory frequency Poisoning area under the curve monoamine oxidase median lethal dose Mean residence time EEG terminal elimination half-life homovanillic acid Platelet rich plasma HVA Liquid chromatography-high resolution mass spectrometry high-performance liquid chromatography HPLC total clearance GABA mu-opioid receptor

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose?

Authors

Camille Lagard, Lucie Chevillard, Isabelle Malissin, Patricia RisÃ¨de, Jacques Callebert, Laurence Labat, Jean-Marie Launay, Jean-Louis Laplanche, Bruno Mégarbane,