| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8540402 | Vascular Pharmacology | 2018 | 10 Pages |
Abstract
Vascular adaptations to either physiological or pathophysiological conditions commonly require gene expression modifications in the most represented cellular elements of the vessel wall, i.e. endothelial and smooth muscle cells. In addition to transcription factors, a number of mechanisms contribute to the regulation of gene expression in these cells including noncoding RNAs, histone and DNA modifications, collectively indicated as epigenetic modifications. Here, we summarize the state of art regarding the role of epigenetic changes in major vascular diseases, and discuss the potential diagnostic and therapeutic applications of epigenetic modulation in this context.276
Keywords
CpGmRNAsAAAWKYSirtuinsPASMCsAGEsTETeNOSECMIL-1βRAAS5-hmCHDACiT2DlncRNAsEPCsncRNAsSNPsmiRsTGF-βMMPTIMP1EndMTECFCsHDACsoxLDLeRNAsenhancer RNAsPAHVSMCsPAECsDNMTs5-mC5-Methylcytosine5-hydroxymethylcytosineCVDsECsNAD+circular RNAsnon-coding RNAsMessenger RNAsEndothelial-to-mesenchymal transitionEpigeneticsInterleukin-1βPeripheral artery diseaseCardiovascular diseasestransforming growth factor-βten-eleven translocationType 2 diabetesmicroRNAsSirtsVascular smooth muscle cellspulmonary artery smooth muscle cellsSmooth muscle cellsEndothelial progenitor cellsEndothelial cellsPulmonary artery endothelial cellsendothelial colony-forming cellsendothelial nitric oxide synthasecircRNAsRenin-angiotensin-aldosterone systemShrhypoxia-inducible factor-1αVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Pulmonary arterial hypertensionLysineOxidized low density lipoproteinsExtracellular matrixmatrix metalloproteinaseMethylationAdvanced glycation end productsUTR یا untranslated regions Tissue inhibitor of metalloproteinase 1Spontaneously hypertensive ratsNucleotidesnicotinamide adenine dinucleotidehistone deacetylaseshistone acetyl-transferaseWistar KyotoPADSingle nucleotide polymorphismsHAT
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Authors
Gabriele G. Schiattarella, Rosalinda Madonna, Sophie Van Linthout, Thomas Thum, Rainer Schulz, Peter Ferdinandy, Cinzia Perrino,