UDP-sugars activate P2Y14 receptors to mediate vasoconstriction of the porcine coronary artery

Article ID	Journal	Published Year	Pages	File Type
8540509	Vascular Pharmacology	2018	40 Pages	PDF

Abstract

Our data support a role of UDP-sugars as extracellular signalling molecules and show for the first time that they mediate contraction of porcine coronary arteries via P2Y14 receptors.

Keywords

PBS NTPDase1 P2Y14 receptor P2Y6 receptor VASP PPTN TBST PAGE DAPI RCF ERK KCl FITC SDS 1,4-diazabicyclo[2.2.2]octane 4′,6-diamidino-2-phenylindole BSA l-NAME MAPK Nω-nitro-l-arginine methyl ester Tris-buffered saline and Tween 20 bovine serum albumin polyacrylamide gel electrophoresis Oct DABCO sodium dodecyl sulphate Coronary artery Phosphate buffered saline Vasodilator-stimulated phosphoprotein fluorescein isothiocyanate Sugar nucleotides sodium nitroprusside Nitric oxide relative centrifugal force SNP Potassium chloride extracellular signal-regulated kinases mitogen-activated protein kinases UDP-glucose

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

UDP-sugars activate P2Y14 receptors to mediate vasoconstriction of the porcine coronary artery

Authors

Zainab S.B. Abbas, M. Liaque Latif, Natalia Dovlatova, Sue C. Fox, Stan Heptinstall, William R. Dunn, Vera Ralevic,