| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8544733 | Chemico-Biological Interactions | 2018 | 42 Pages |
Abstract
In conclusion, PXR activation and PXR-mediated induction of CYP3A4 expression by PAs seem to be structure-dependent. Data suggest that only open-chain diesters act as PXR agonists. This might imply that a PXR-mediated mode of action may contribute to the hepatotoxicity of PAs that is dependent on PA structure.
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Authors
Claudia Luckert, Albert Braeuning, Alfonso Lampen, Stefanie Hessel-Pras,