Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8544863 | Chemico-Biological Interactions | 2018 | 32 Pages |
Abstract
An in-vivo study was conducted wherein arsenic as sodium arsenite (100â¯ppm) was administered in drinking water for 5 months to Swiss albino mice. This was followed by a treatment protocol comprising of curcumin encapsulated chitosan nanoparticles (nano-curcumin, 15â¯mg/kg, orally for 1 month) either alone or in combination with MiADMSA encapsulated polymeric nanoparticles (nano-MiADMSA, 50â¯mg/kg for last 5 days) to evaluate the therapeutic potential of the combination treatment. Our results demonstrated that co-treatment with nano-curcumin and nano-MiADMSA provided beneficial effects in a synergistic way on the adverse changes in oxidative stress parameters and metal status induced by arsenic.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Pramod Kushwaha, Abhishek Yadav, M. Samim, S.J.S. Flora,