Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8545454 | Chemico-Biological Interactions | 2017 | 38 Pages |
Abstract
A supra-linear relationship between metabolite concentrations and benzene exposure was observed over the range 0.1-10Â ppm benzene, however over the range benzene exposures of between 0.1 and 1Â ppm only a modest departure from linearity was observed. The molar fractions estimated in this work were near constant over the range 0.1-10Â ppm. No evidence of high affinity metabolism at these low level exposures was observed. Our reanalysis brings in to question the appropriateness of the dataset for commenting on low dose exposures and the use of a purely statistical approach to the analysis.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
K. McNally, C. Sams, G.D. Loizou, K. Jones,