Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8545643 | Chemico-Biological Interactions | 2016 | 9 Pages |
Abstract
The results showed ATO inhibited LXR-β mRNA and protein levels with a subsequent decrease in SREBP-1c protein levels and reduced cholesterol efflux from HepG2 cells into the extracellular space without influencing LXR-α mRNA and protein levels. CETP protein levels of HepG2 cells were significantly elevated under arsenic exposure. Transfection of LXR-β shRNA did not change CETP protein levels, implying that there is no cross-talk between LXR-β and CETP. In conclusion, arsenic not only inhibits LXR-β and SREBP-1c mRNA and protein levels but also independently increases CETP protein levels in HepG2 cells.
Keywords
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Authors
Tain-Junn Cheng, Shu-Wen Lin, Chih-Wei Chen, How-Ran Guo, Ying-Jang Wang,