| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8545898 | Environmental Toxicology and Pharmacology | 2018 | 5 Pages |
Abstract
The results of this study showed that administration with either lead acetate or mercury chloride caused degenerative damage in seminiferous tubules and reduction in sperm quality and expression of CatSper 1, 2 genes in mice. Therefore, it is possible in infertile men who have had exposure to lead acetate or mercury chloride. Owing to structural similarities, these metals are substitutes for calcium ions and have effects on calcium channels. These cause immobility in sperm by blocking CatSper-specific calcium channels. However, more studies are required to elucidate the mechanism underlying the impact of different doses of heavy metals on CatSper genes expression.
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Authors
Sh. Mohammadi, M Gholamin, M. Mohammadi, A. Mansouri, R. Mahmoodian, S. Attari, S.M. Kebriaei, B. Zibaei, M. Roshanaei, F. Daneshvar, M. Khandehro, M.A. Khodadadegan, A. Delshad, F. Mohammadzadeh, Mostafa Peyvandi, Majid Ghayour-Mobarhan,