Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8545955 | Environmental Toxicology and Pharmacology | 2018 | 7 Pages |
Abstract
Gut microbiome dysbiosis plays a profound role in the pathogenesis of obesity and tributyltin (TBT) has been found as an environmental obesogen. However, whether TBT could disturb gut microbiome and the relationship between obesity induced by TBT exposure and alteration in gut microbiota are still unknown. In order to assess the association between them, mice were exposed to TBTCl (50â¯Î¼gâ¯kgâ1) once every three days from postnatal days (PNDs) 24 to 54. The results demonstrated that TBT exposure resulted in increased body weight gain, lager visceral fat accumulation and dyslipidemia in male mice on PND 84. Correspondingly, 16S rRNA gene sequencing revealed that TBT treatment decreased gut microbial species and perturbed the microbiome composition in mice. Furthermore, Pearson's corelation coefficient analysis showed a significantly negative correlation between the body weight and the alpha diversity of gut microbiome. These results suggested that TBT exposure could induce gut microbiome dysbiosis in mice, which might contribute to the obesity pathogenesis.
Keywords
HFDrRNAPCoATributyltinTBTPPARγHSDMSCPNDEDCRDPRibosomal RNADyslipidemiaOUTPrincipal Coordinate Analysistriglyceridepostnatal dayhigh-fat diethigh-sucrose dietendocrine disrupting chemicalLow-density lipoproteinLDLObesityoperational taxonomic unitribosomal database project16S ribosomal RNA genetotal cholesterol
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Hao Guo, Haotian Yan, Dong Cheng, Xinglong Wei, Ruirui Kou, Jiliang Si,