Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8546066 | Environmental Toxicology and Pharmacology | 2017 | 51 Pages |
Abstract
Fluoride is ubiquitous in environment and profound in bones, teeth and calcified tissues of human body. Fluoride has been the topic of regular discussion and investigations. Besides its toxicity, fluoride has also been examined for its beneficial effects like prevention and treatment of tooth decay, microbial infection, inflammation, cancer, occurrence of renal stone and many more. Since last many decades, several efforts have been made at pre-clinical and clinical level to understand role of fluoride in biological system. The present review gives a brief account of prevalence, sources of fluoride toxicity and pre-clinical and clinical studies carried out on effects of fluoride in last six decades.
Keywords
EPAIL-1βIL-17iNOSppmSDHIL-8p38MAPKPFOSmRNAPFOAPGI2NaFICMRMKK6messenger RNAEnvironmental Protection AgencyStrontiumInterleukin-8interleukin-17Interleukin-1βpart per millionBIStumor necrosis factor-αWorld Health Organizationinducible nitric oxide synthaseIndian Council of Medical ResearchTNF-αSodium fluorideMicroRNAMiRNANitric oxidePerfluorooctanoic acidp38 mitogen-activated protein kinaseprostacyclinWHOGABA
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Authors
Divya Sharma, Aarti Singh, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma, Jaya Dwivedi,