Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8549502 | International Journal of Hygiene and Environmental Health | 2018 | 5 Pages |
Abstract
Reference values (RV95) are statistically derived values comprising the rounded 95th percentiles within the 95% confidence interval and indicate the upper margin of background exposure to chemical substances in a population at a given time period. Based on representative national human biomonitoring data on several urinary phthalate metabolites in children, adolescents and adults from 2010 to 2011, RV95 were derived for the Austrian population based on a IUPAC guideline and the recommendation of the German Human Biomonitoring Commission. The RV95 (rounded values) for phthalate metabolites in children and adolescents aged 6-15 years are 110â¯Î¼g/l (confidence interval of 95th population percentile: 83.7-163) for mono-ethyl phthalate (MEP), 45â¯Î¼g/l (40.9-60.6) for mono-n-butyl phthalate (MnBP), 130â¯Î¼g/l (126-161) for mono-isobutyl phthalate (MiBP), 25â¯Î¼g/l (17.8-33.6) for mono-benzyl phthalate (MBzP), 100â¯Î¼g/l (94.0-126) for the sum of the di(2-ethylhexyl) phthalate (DEHP) metabolites including mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP) and mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP), and 1.5â¯Î¼g/l (0.64-1.6) for mono-cyclohexyl phthalate (MCHP). In adults aged 18-81 years, RV95 are 440â¯Î¼g/l (353-636) for MEP, 40â¯Î¼g/l (33.1-52.1) for MnBP, 110â¯Î¼g/l (87.3-118) for MiBP, 10â¯Î¼g/l (7.2-11.8) for MBzP, 50â¯Î¼g/l (44.6-68.3) for the sum of MEHP, 5OH-MEHP, 5oxo-MEHP and 5cx-MEPP, and 1.5â¯Î¼g/l (0.95-1.8) for MCHP. For almost all investigated metabolites, children and adolescents exhibit higher RV95 than adults, with the exceptions being MEP and MCHP. Compared to available RV95 for Germany and Canada, Austrian values are lower for all investigated population groups.
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Authors
Christina Hartmann, Maria Uhl, Stefan Weiss, Sigrid Scharf, Jürgen König,