Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8550084 | NeuroToxicology | 2018 | 10 Pages |
Abstract
The present findings suggest that the interaction of tariquidar with atropine may be the decisive factor for enhanced treatment efficacy, given that atropine was previously found to be a PgP substrate. A more thorough understanding of the interactions of nerve agent antidotes, in particular the actions of central anticholinergics with benzodiazepines, could contribute to a future optimization of treatment combinations, particularly those aimed at later stage medical interventions.
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Authors
Gideon F. Meerhoff, Stefanie M. Vester, Peter Hesseling, Steven D. Klaassen, Alex S. Cornelissen, Paul J. Lucassen, Marloes J.A. Joosen,