Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8550123 | NeuroToxicology | 2018 | 24 Pages |
Abstract
For most drugs, IC50 values are close to the estimated human brain concentrations following recreational doses of these drugs, highlighting the importance of this efficient in vitro screening approach for classification and prioritization of emerging NPS. Moreover, the wide range of IC50 values observed for these and previously tested drugs of abuse, both within and between different classes of NPS, indicates that additional investigation of structure-activity relationships could aid future risk assessment of emerging NPS.
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Authors
Anne Zwartsen, Laura Hondebrink, Remco HS Westerink,