Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8550872 | Regulatory Toxicology and Pharmacology | 2018 | 50 Pages |
Abstract
To clarify these discrepant positions, the function and regulation of the thyroid gland are described and the types of thyroid tumors and the causes of their development in humans and animals are examined. Based on these data and the evidence that so far, except radiation, no chemical is known to increase the incidence of thyroid tumors in humans, it is concluded that rodent thyroid tumors resulting from continuous stimulation of the thyroid gland by increased TSH levels are not relevant to humans. Consequently, compounds that induce such tumors do not warrant classification as carcinogenic.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Ruediger Bartsch, Britta Brinkmann, Gunnar Jahnke, Britta Laube, Ruth Lohmann, Sandra Michaelsen, Ingrid Neumann, Helmut Greim,