Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8551185 | Regulatory Toxicology and Pharmacology | 2018 | 16 Pages |
Abstract
The residue behavior and dietary intake risks of carbosulfan and its metabolites in cucumbers were investigated. A quick and reliable method for determining carbosulfan and its metabolite residues in cucumbers was established using ultrahigh performance liquid chromatography-tandem mass spectrometry. The fortified recoveries ranged from 87.2% to 91.0% with relative standard deviations of 3.2%-8.1%. The dissipation results showed that carbosulfan was transformed into carbofuran and 3-hydroxy carbofuran in cucumbers. The half-life of carbosulfan was 1.5 days, and the half-life of carbofuran was 45 days. The final residues of carbosulfan varied from 0.245 to 0.005â¯mg/kg and carbofuran varied from 0.123 to 0.008â¯mg/kg. After a 5-day application period the residues of carbosulfan was 0.113â¯mg/kg that was below the maximum residue limit set by China (0.2â¯mg/kg), and the residues of carbofuran was 0.055â¯mg/kg that was higher than the maximum residue limit set by China (0.02â¯mg/kg). The risk assessment results indicated that the dietary intake risks of carbosulfan and carbofuran from cucumber consumption were safe for Chinese consumers, but pre-harvest intervals should be strictly recommended for 7 days at the recommended dose to ensure that food quality conforms to the MRL standard. This study provides a method and data for scientifically evaluating dietary intake risks of carbosulfan and its more toxic metabolites.
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Authors
Wencheng Song, Chunhong Jia, Junjie Jing, Ercheng Zhao, Min He, Li Chen, Pingzhong Yu,