Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8551196 | Regulatory Toxicology and Pharmacology | 2018 | 22 Pages |
Abstract
In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately. C/LA complex effectively restored the level of DA metabolites: the level of DOPAC was increased by 24.7â¯Â±â¯5.6% compared to the animals that had received MPTP only, and the level of HVA was restored to the values observed in the intact animals. Integral metabolic indices of DA (DOPAC/DA and HVA/DA ratios) and 5-HT turnover (5-HIAA/5-HT ratio) in the striatum tended to increase in case of C/LA complex administration.
Keywords
5-HTMDA3-MTDOPACMPTPLPO4-hydroxynonenal4-HNE1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine5-Hydroxyindoleacetic acidROSα-Lipoic acidHomovanilic acidHIAAParkinson's diseaseOxidative stressDopaminemalonic dialdehydeNeuroprotectionRatnoradrenalinLipid peroxidationHVAcatecholaminesCarnosinehigh-performance liquid chromatographyHPLCReactive oxygen species
Related Topics
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Authors
Olga I. Kulikova, Daniil S. Berezhnoy, Sergey L. Stvolinsky, Alexander V. Lopachev, Valentina S. Orlova, Tatiana N. Fedorova,