Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8551256 | Regulatory Toxicology and Pharmacology | 2018 | 44 Pages |
Abstract
This study aimed to investigate the effects of beta-cypermethrin (β-CYP) on female reproductive function and examine the morphology of the uterine endometrium and follicular development. The results found that the rate of successful pregnancy in the β-CYP-treated groups significantly decreased. The levels of serum E2 and FSH were significantly increased in the β-CYP-treated groups. The concentrations of serum P and LH were significantly decreased in the β-CYP-treated groups. The uterine endometrium was damaged and the endometrial pinopode was markedly inhibited. In addition, the total number of follicles of all types was significantly lower in the medium- and high-dose β-CYP-treated groups. These results suggest that β-CYP significantly affected the reproductive function of female mice. β-CYP may have significantly decreased the fertility of female mice by disturbing the reproductive hormone concentrations and inhibiting the development of the endometrium and the endometrial pinopode.
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Authors
Yong-jiang Zhou, Xiao-dan Wang, Sha Xiao, De-E Yu, Li-qing Wang, Ji-hong Wang, Hui-quan Zhu,