Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552134 | Reproductive Toxicology | 2018 | 21 Pages |
Abstract
Ibuprofen is an analgesic frequently used in the 1st and 2nd trimester of pregnancy. Most relevant studies deal with NSAID as a group and do not specifically focus on ibuprofen. In this study, 1117 women exposed to ibuprofen in the 1st trimester were compared to 2229 non-exposed women. Data were retrieved from the German Embryotox database. No significantly increased risk of major birth defects (4.8% vs. 4.1%; OR adjusted 1.11, 95% CI 0.75-1.64) or a distinct pattern of birth defects were found. The cumulative incidences of spontaneous abortions were similar across cohorts (15.5% vs. 16.6%; HR adjusted 0.85; 95% CI, 0.65-1.11). Subgroup analyses of pregnancies exposed for â¥7 (nâ¯=â¯223) and â¥30â¯days (nâ¯=â¯72) did not reveal a higher risk with increasing treatment duration. Ibuprofen does not seem to carry a substantial embryotoxic risk regarding the investigated endpoints.
Keywords
IPTWEuropean Surveillance of Congenital AnomaliesNBDPSMedDRACIGADJadjustedElective termination of pregnancyLMPMoBaETOPSABOTCHCPNSAIDCOXORadjlast menstrual periodcyclooxygenaseinverse probability of treatment weightingover the counterNonsteroidal anti-inflammatory drugsMedical Dictionary for Regulatory Activitiesabortionsspontaneous abortionCigarettesNumberAnti-inflammatory agentsconfidence intervalHealth care professionalsNational Birth Defects Prevention Studymilligramhazard ratioodds ratioApgar scorePropensity scoregestational weekEUROCAT
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Authors
Katarina Dathe, Anne-Katrin Fietz, Lucas William Pritchard, Stephanie Padberg, Stefanie Hultzsch, Katja Meixner, Reinhard Meister, Christof Schaefer,