Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552308 | Reproductive Toxicology | 2018 | 24 Pages |
Abstract
Tetrabutyltin is a stable organotin and may exhibit endocrine disrupting properties. Herein, we investigated effects of tetrabutyltin on the development of rat fetal Leydig cells, which support differentiation of the male reproductive tract in late gestation. Female pregnant Sprague Dawley rats were gavaged with tetrabutyltin (0, 100, 200, and 500â¯mg/kg) from gestational day (GD) 12 to GD 21. Tetrabutyltin dose-dependently decreased testicular testosterone levels (0.756â¯Â±â¯0.208 and 0.813â¯Â±â¯0.277â¯ng/testis at the 200 and 500â¯mg/kg doses, respectively) compared to control (1.692â¯Â±â¯0.218â¯ng/testis) at GD 21. Furthermore, tetrabutyltin induced fetal Leydig cell aggregation, decreased fetal Leydig cell size and cytoplasmic size at the â¥100â¯mg/kg doses, and downregulated the expression levels of Scarb1, Cyp17a1, and Insl3 at doses â¥100â¯mg/kg and Star expression at 200â¯mg/kg. Taking together, the present results indicated that prenatal exposure of male rats to tetrabutyltin affected fetal Leydig cell development.
Keywords
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Authors
Yaoyao Dong, Yu Zhao, Qiqi Zhu, Zhe Wang, Yuanyuan Shan, Benson T. Akingbemi, Ruijie Chen, Lihe Zhu, Ren-Shan Ge,