Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552342 | Reproductive Toxicology | 2018 | 40 Pages |
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that has been shown to impair normal reproductive function in males and females. This study investigated whether adult exposure to environmental and occupational doses of DEHP alters homeostasis of uterine proliferation, morphology, and number of uterine glands. Adult female CD1 mice were orally dosed with DEHP (0, 20â¯Î¼g/kg/day, 200â¯Î¼g/kg/day, 20â¯mg/kg/day or 200â¯mg/kg/day) for 30â¯days. Results indicated that DEHP at 200â¯Î¼g/kg/day caused a reduction in epithelial cell proliferation in the uterus (pâ¯<â¯.05). We also observed an increase (pâ¯<â¯.05) in the number of uterine glands in mice dosed with 200â¯mg/kg/day DEHP. Results showed that DEHP caused an increase (pâ¯<â¯.05) in dilated blood vessels in the endometrium at 200â¯Î¼g/kg/day, 20â¯mg/kg/day and 200â¯mg/kg/day. DEHP also increased proliferation of endometrial stromal cells at 200â¯Î¼g/kg/day DEHP (pâ¯<â¯.0010), 20â¯mg/kg/day DEHP (pâ¯<â¯.0001) and 200â¯mg/kg/day DEHP (pâ¯<â¯.0186). Results suggest that, exposure to specific doses of DEHP for 30â¯days can have adverse effects on reproductive function.
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Authors
Kadeem A. Richardson, Patrick R. Hannon, Yvette J. Johnson-Walker, Maung Sun Myint, Jodi A. Flaws, Romana A. Nowak,