Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552504 | Reproductive Toxicology | 2018 | 6 Pages |
Abstract
Peroxisome-proliferator activated receptor gamma (PPARG) in placenta play an important role in pregnancy. Our previous study showed that it mediated the effects of phthalates on placental mRNA expression of estrogen synthetases in rats. To assess the effects of phthalate exposure on PPARG placental expression, and the contribution of PPARG to the effects of phthalates in human. 207 healthy pregnant women were recruited and their cord blood and placenta were collected upon delivery. Three phthalates, estrogens in cord blood and protein expression of PPARG in placenta were measured. Linear regression were used to analyze the relationship between phthalates exposure, PPARG expression and hormones. Phthalate levels in cord blood were positively associated with PPARG protein expression in placenta (p < 0.05), whereas estrogens in cord blood were negatively associated with phthalate levels and PPARG expression (p < 0.05). This study shows that PPARG in placenta may mediate the adverse effects of phthalates on pregnancy in human.
Keywords
PIHPPARGMmpsDBPICPdibutyl phthalateDIBPGDMPROMMEHPBPDdi-isobutyl phthalateDEHPdi-(2-ethylhexyl) phthalatemono-(2-ethylhexyl) phthalateEstradiolEstrogensestriolPregnancyIntravenous infusionhead circumferenceAbdominal circumferenceGestational diabetes mellitusbody mass indexBMIFemur lengthPhthalatesBiparietal diametermatrix metalloproteinasePremature rupture of membranesProgesteroneIntrahepatic cholestasis of pregnancyperoxisome proliferator activated receptors
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Authors
Yujing Huang, Jose M. Garcia, Weiqun Shu, Honghui Rong, Lin Zhang, Yanzhou Wang, Yao Tan, Hui Lin, Hui Zeng, Ji-an Chen,