Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552678 | Reproductive Toxicology | 2017 | 39 Pages |
Abstract
Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. This study aimed to evaluate whether ascorbic acid supplementation may prevent the reproductive damage provoked by rosuvastatin administration at prepuberty. Male pups were distributed into six experimental groups that received saline solution 0.9%, 3 or 10Â mg/kg/day of rosuvastatin, 150Â mg/day of ascorbic acid, or 150Â mg/day of ascorbic acid associated with 3 or 10Â mg/kg/day of rosuvastatin from post-natal day (PND) 23 until PND53. Rosuvastatin-treated groups showed delayed puberty installation, androgen depletion and impairment on testicular and epididymal morphology. Ascorbic acid partially prevented these reproductive damages. In conclusion, rosuvastatin exposure is a probable risk to reproductive development and ascorbic acid supplementation may be useful to prevent the reproductive impairment of rosuvastatin exposure.
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Authors
Gabriel Adan Araújo Leite, Thamiris Moreira Figueiredo, Marciana Sanabria, Ana Flávia Mota Gonçalves Dias, PatrÃcia Villela e Silva, Airton da Cunha Martins Junior, Fernando Barbosa Junior, Wilma De Grava Kempinas,