Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8552705 | Toxicology | 2018 | 8 Pages |
Abstract
How does estrogen receptor-α bind its natural ligands - estrogens? How can other molecules mimic estrogens and elicit different estrogenic responses? The answers lie in a complex and intimate chemical biology between ligands and receptor. This delicate interaction at the ligand binding cleft signals, via conformational change, exposure of a specific new charge topography at a second site (Activation Function-2). This, in turn, attracts a regulatory protein which modulates gene expression and controls biological activity.
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Authors
Hui Ye, Samantha Z. Dudley, Ian C. Shaw,