| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8552750 | Toxicology | 2018 | 10 Pages |
Abstract
In summary, our results indicate that in mice CYP activity and gene expression are strain dependent and may vary highly between liver lobes. To ensure reproducibility and comparability of different probes and studies, this should be taken into account when liver samples are collected for the analysis of CYP-dependent metabolism.
Keywords
PXRRLTPBSALAS1AHROECDCyPMRODRLUNADPHFDABCAHRSBSAbovine serum albuminCPRU.S. Food and Drug Administrationbicinchoninic acidOrganisation for Economic Co-operation and Developmentcytochrome P450 reductaseCytochrome P450Phosphate buffered salineCARMouseWeighted averageLiver microsomesrelative luminescence unitsHorseradish peroxidasereduced nicotinamide adenine dinucleotide phosphatearyl hydrocarbon receptorconstitutive androstane receptor
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Authors
Juliane Rudeck, Bettina Bert, Philip Marx-Stoelting, Gilbert Schönfelder, Silvia Vogl,