Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays

Article ID	Journal	Published Year	Pages	File Type
8552945	Toxicology	2018	41 Pages	PDF

Keywords

GSH STX TMD MXR NRF-2 H2DCF-DA DHLA P-gp NDA GTX NBD GST TCA Gonyautoxin PDB PBS P-SH Rho123 DMEM Kelch like ECH associated protein 1 FEB DFT DMSO MTT P-glycoprotein ROS Antioxidant trichloroacetic acid Free energy of binding Homo highest occupied molecular orbital nucleotide binding domain transmembrane domain CNS Rhodamine 123 blood brain barrier BBB Saxitoxin Saxitoxins central nervous system antioxidant response element Keap 1 Phosphate buffered saline LUMO Lipoic acid Multixenobiotic resistance Neurotoxin ARE Verapamil Protein Data Bank Molecular docking reduced glutathione Lowest Unoccupied Molecular Orbital glutathione-S-transferase Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays

Authors

PatrÃcia Ramos, Marcos Schmitz, Sibele Gama, Aline Portantiolo, Michael Gonzalez Durruthy, Ana Paula de Souza Votto, Luisa Rodrigues Cornetet, Karina dos Santos Machado, Adriano Werhli, Mariana Zancan Tonel, Solange Binotto Fagan, JoÃ£o Sarkis Yunes,