| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553168 | Toxicology Letters | 2018 | 31 Pages |
Abstract
In summary, the extensive differences in miRNA expression pattern between these cell lines indicate that specific miRNAs may play a role in the resistance mechanism against sulfur mustard. The miR-125b-2 and miR-181b alone are not responsible for the resistance development against SM, but an ectopic increase of miR-181 even enhances the SM resistance of HaCaT/SM. Improving the resistance in normal keratinocytes by treatment with either both miRNAs together or a different combination might be used as an initial step in development of an innovative new drug or prophylactic agent against SM.
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Authors
Simone Rothmiller, Markus Wolf, Franz Worek, Dirk Steinritz, Horst Thiermann, Annette Schmidt,