| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553195 | Toxicology Letters | 2018 | 7 Pages |
Abstract
SM exposure of MSC leads to adduct formation on chromosomal DNA. These DNA adducts can be reduced without MSC are undergoing apoptosis. This indicates an active DNA damage response (DDR) pathway in combination with the formation of persistent nuclear DNA damage foci. This process is accompanied by a reduced capability of proliferation and a transition into the senescent state.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Annette Schmidt, Dirk Steinritz, Simone Rothmiller, Horst Thiermann, A. Michael Scherer,