| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553197 | Toxicology Letters | 2018 | 13 Pages |
Abstract
This study demonstrated that TMAB001 could reach the drug target sites-retina and choroid after a single bilateral IVT administration in rabbits and monkeys, with a long t1/2 in vitreous humor. TMAB001 also showed strong capability to neutralize VEGF. The study further confirmed that full-length antibodies can also efficiently diffuse and distribute in ocular tissues.
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Authors
Dong-An Yu, Meng You, Wan-Wan Ji, You Lu, Bin Liu, Shou-Sheng Yan,