| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553212 | Toxicology Letters | 2018 | 10 Pages |
Abstract
The residual fourteen BP compounds, possessing either an isopropyl-group or more than one group at the pyridinium moiety, antagonized nicotinic currents exhibiting IC50 of low up to high micromolar concentrations (â¼Â 1 μM-300 μM).
Keywords
MLABispyridiniumPNU-120596α7-nicotinic acetylcholine receptornicotinic acetylcholine receptor(s)PAMAChAChEAcetylcholineAcetylcholinesteraseOrganophosphorus compoundOrganophosphorus compoundsTrifluoromethanesulfonateCNScentral nervous systemperipheral nervous systemActivationmethyllycaconitine citratepositive allosteric modulatorAllosteric modulationPNSDesensitizationAutomated patch clampIodide
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Authors
Corinna Scheffel, Karin V. Niessen, Sebastian Rappenglück, Klaus. T. Wanner, Horst Thiermann, Franz Worek, Thomas Seeger,