Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor

Article ID	Journal	Published Year	Pages	File Type
8553218	Toxicology Letters	2018	36 Pages	PDF

Keywords

FIA mAChR HI-6 (HP)LC MRM PCP nAChR NSB TRIS FDA MB327 ESI LLOQ CXP nuclear magnetic resonance 2-amino-2-(hydroxymethyl)propane-1,3-diol LC–MS S/N AChE Nonspecific binding internal standard Acetylcholinesterase collision energy Flow injection analysis NMR lower limit of quantification Food and Drug Administration Signal-to-noise Mass spectrometry Phencyclidine Reverse phase multiple reaction monitoring HILIC declustering potential collision cell exit potential entrance potential hydrophilic interaction chromatography quality control muscarinic acetylcholine receptor nicotinic acetylcholine receptor electrospray ionization

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor

Authors

S. Sichler, G. Höfner, S. Rappenglück, T. Wein, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, F.F. Paintner, K.T. Wanner,