Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8553273 | Toxicology Letters | 2018 | 7 Pages |
Abstract
Constitutive androstane receptor (CAR) is a nuclear receptor that not only regulates drug-metabolizing enzymes but also influences energy metabolism. TC, 1, 4-bis [2-(3, 5-dichloropyridyloxy)] benzene (TCPOBOP) has been shown to inhibit lipogenesis in the liver and adipose tissues. The mammary gland is mainly composed of fat pads and duct systems in adolescent female mice. Here, activation of CAR by TC reduces the mammary gland weight, blocks lipid accumulation by inhibiting lipogenesis and gluconeogenesis, and accelerates collagen formation and fibrosis in the mammary fat pad of adolescent female mice. This information provides a reference for CAR activation, which may affect mammary gland development in adolescent females.
Keywords
ACCα-SMAPGC1αFASGAPDHG6PasePEPCKPAI-1H&EIgf1Alpha-smooth muscle actinacetyl-CoA carboxylasefatty acid synthaseGonadal white adipose tissueinsulin-like growth factor 1phosphoenolpyruvate carboxykinaseCARPlasminogen activator inhibitor-1Hematoxylin and Eosinglucose-6-phosphataseglyceraldehyde-3-phosphate dehydrogenaseconstitutive androstane receptor
Related Topics
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Authors
Pengfei Xu, Fan Hong, Jing Wang, Shu Dai, Jialin Wang, Yonggong Zhai,