Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice

Article ID	Journal	Published Year	Pages	File Type
8553297	Toxicology Letters	2018	42 Pages	PDF

Keywords

N-acetyl-p-benzoquinone imine TBARS 3-NT APAP HO-1 UGT1A1 GPX NAC GSH NAPQI Nrf2 CAT GCLC CYP2E1 c-Jun-N-terminal kinase Jnk RIP1 IL-6 3-Nitro-tyrosine ALT ERK1/2 MAPK N-acetylcysteine ROS AST Aspartate aminotransferase Acute liver injury Alanine aminotransferase Acetaminophen Ali interleukin-6 tumor necrosis factor-α TUNEL Liver protection SOD Superoxide dismutase cytochrome P450 2E1 Anti-apoptosis Anti-inflammation Anti-oxidation TNF-α nuclear factor erythroid 2-related factor 2 thiobarbituric acid reactive substances heme oxygenase 1 mitogen-activated protein kinase Kaempferol Catalase Glutamate cysteine ligase catalytic subunit extracellular signal-regulated kinase 1/2 Glutathione glutathione peroxidase Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice

Authors

Ming-Shiun Tsai, Ying-Han Wang, Yan-Yun Lai, Hsi-Kai Tsou, Gan-Guang Liou, Jiunn-Liang Ko, Sue-Hong Wang,