| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553311 | Toxicology Letters | 2018 | 27 Pages |
Abstract
Our research objective was to determine whether inhaled NAC might also be therapeutic for other chemicals, in this case, phosgene. This study has demonstrated that multiple nebulised doses, administered from 30â¯min after exposure of terminally anaesthetised pigs to phosgene, is not an effective therapy when administered at the times and doses employed in this study. There remains no pharmacological treatment for phosgene-induced lung injury.
Keywords
EndotrachealBALGSSGPaCO2TICWBCPaO2NACGSHARDSFiO2PEEPCOTSCommercial Off the ShelfTASN-acetylcysteineROSAcute lung injuryEDTAchronic obstructive pulmonary disorderInhalationECGelectrocardiogramAliCOPDANOVATreatmentSODToxicityAcute respiratory distress syndromeSuperoxide dismutasephosgenePositive end expiratory pressurebronchoalveolar lavageASBToxic industrial chemicalTotal antioxidant statusFraction of inspired oxygenwhite blood cellglutathione disulphideglutathione reductaseglutathione peroxidasePorcineReactive oxygen speciesone way analysis of variance
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Rachel Rendell, Sarah Fairhall, Stuart Graham, Steve Rutter, Philippa Auton, Adam Smith, Rosi Perrott, Bronwen Jugg,