d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions

Article ID	Journal	Published Year	Pages	File Type
8553330	Toxicology Letters	2018	8 Pages	PDF

Keywords

AGEs VADC RAPA TXNIP LECs HCQ sirtuin 1 MPTP GAPDH NAC Sirt1 MMP DOX D-galactose MAPK N-acetylcysteine ROS Adenosine Triphosphate ATP Mitochondrial dysfunction mitochondria permeability transition pore Oxidative stress d-gal Doxorubicin Rapamycin lens epithelial cells Autophagy flux Metformin Advanced glycation end products MET hydroxychloroquine Mitochondrial membrane potential thioredoxin-interacting protein mitogen-activated protein kinase Premature senescence voltage dependent anion channel glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions

Authors

Yao Xu, Yong Li, Limei Ma, Guang Xin, Zeliang Wei, Zhi Zeng, Zhihua Xing, Shiyi Li, Hai Niu, Wen Huang,