Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8553777 | Toxicology in Vitro | 2018 | 12 Pages |
Abstract
It was shown that embryo exposure to temporary consolidants resulted in an increased mortality and malformation rate, and a decreased hatching rate. The order of embryo toxicity of the four types of temporary consolidants tested was mentholâ¯>â¯coumarinâ¯>â¯ethyl maltolâ¯>â¯cyclododecane. Although the embryo toxicity of cyclododecane was minimal, some studies have indicated that this temporary consolidant could be bioaccumulated. The results also suggested that the zebrafish embryos can serve as a reliable model for the evaluation of embryo toxicity of temporary consolidants, as this model could offer the possibility to perform the rapid, medium throughput, cost-effective analyses.
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Authors
Lu Zhang, Xiao Yan Zhang, Yulan Hu, Bing Jian Zhang,