| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553861 | Toxicology in Vitro | 2018 | 31 Pages |
Abstract
For the SkinEthic⢠HCE EIT test method, 100% concordance in predictions (No Cat versus No prediction can be made) between the two participating laboratories was obtained. The accuracy of the SkinEthic⢠HCE EIT was 97.5% with 100% sensitivity and 96.9% specificity. The SkinEthic⢠HCE EIT confirms its excellent results of the validation studies.
Keywords
HCE3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromideEURL ECVAMRhCEreconstructed human cornea-like epitheliumCAS RNCON4EICaT1BCOPEU CLPCAT2SMISlug Mucosal IrritationEITOECDFlemish Institute for Technological ResearchSOPCONsortium for in vitro Eye Irritation testing strategyUN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eyePBSUN GHSMTTEuropean Union Reference Laboratory for Alternatives to Animal TestingEye irritation testHuman corneal epitheliumNo CatOcular irritationBovine Corneal Opacity and Permeabilitytest guidelineChemical Abstracts Service Registry Numberstandard operating procedureUnited Nations Globally Harmonized System of Classification and Labelling of ChemicalsOrganisation for Economic Co-operation and DevelopmentPersPersistencePhosphate-buffered salineVITOoptical densitycorneal opacityPositive controlnegative control
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Authors
A.R. Van Rompay, N. Alépée, L. Nardelli, K. Hollanders, V. Leblanc, A. Drzewiecka, K. Gruszka, R. Guest, H. Kandarova, J.A. Sr., S. Verstraelen, E. Adriaens,