| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553864 | Toxicology in Vitro | 2018 | 44 Pages |
Abstract
EpiOcular⢠EIT achieved a sensitivity of 97%, a specificity of 87% and accuracy of 95% and also confirmed its excellent reproducibility (100%) from the original validation. The assay was applicable to all chemical categories tested in this project and its performance was not limited to the particular driver of the classification. In addition to the existing prediction model for dichotomous categorization, a new prediction model for Cat 1 is suggested.
Keywords
CON4EIIsolated Chicken Eye testDPBSCCIsEURL ECVAMGMPBCOPOECDEU CLPSCCsNHEKEITSTESMIUN GHSMTTEye irritation testNo CatOcular irritationGood Laboratory Practicetest guidelineUnited Nations Globally Harmonized System of Classification and Labelling of ChemicalsOrganisation for Economic Co-operation and Developmentconfidence intervalfalse positivefalse negativeoptical densitycorneal opacitynormal human epidermal keratinocytesPositive controlnegative controlCONJCat 1Cat 2Ice
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Authors
H. Kandarova, S. Letasiova, E. Adriaens, R. Guest, J.A. Sr., A. Drzewiecka, K. Gruszka, Nathalie Alépée, Sandra Verstraelen, An R. Van Rompay,