Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8553871 | Toxicology in Vitro | 2018 | 47 Pages |
Abstract
Using this new testing strategy, the sensitivity for predicting GHS Cat 1 and GHS Cat 2 chemicals was 73% and 64%, respectively and the very high specificity of 97% was maintained. None of the Cat 1 chemicals was underpredicted as GHS No Category. Further combination of the EpiOcular time-to-toxicity protocols with other validated in vitro systems evaluated in this project, should enable significant reduction and even possible replacement of the animal tests for the final assessment of the irritation potential in all of the GHS classes.
Keywords
GMPMMASSMISTENHEKEU CLPCCIOECDBCOPEURL ECVAMCCIsDPBSCON4EISCCCONsortium for in vitro Eye Irritation testing strategyUN GHSMTTNo CatGood Manufacturing PracticeBovine Corneal Opacity and Permeabilitytest guidelineUnited Nations Globally Harmonized System of Classification and Labelling of ChemicalsOrganisation for Economic Cooperation and Developmentconfidence intervalfalse positivefalse negativeisolated chicken eyeoptical densitycorneal opacityPositive controlnegative controlCONJCat 1Cat 2Ice
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Authors
Helena Kandarova, Silvia Letasiova, Els Adriaens, Robert Guest, Jamin A. Sr., Agnieszka Drzewiecka, Katarzyna Gruszka, Nathalie Alépée, Sandra Verstraelen, An R. Van Rompay,