Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8553880 | Toxicology in Vitro | 2018 | 32 Pages |
Abstract
The accuracy of the STE test method to identify Cat 1 chemicals was 61.3% with 23.7% sensitivity and 95.2% specificity. If non-soluble chemicals and unqualified results were excluded, the performance to identify Cat 1 chemicals remained similar (accuracy 62.2% with 22.7% sensitivity and 100% specificity). The accuracy of the STE test method to identify No Cat chemicals was 72.5% with 66.2% sensitivity and 100% specificity. Excluding highly volatile chemicals, non-surfactant solids and non-qualified results resulted in an important improvement of the performance of the STE test method (accuracy 96.2% with 81.8% sensitivity and 100% specificity). Furthermore, it seems that solids are more difficult to test in the STE, 71.4% of the solids resulted in unqualified results (solubility issues and/or high variation between independent runs) whereas for liquids 13.2% of the results were not qualified, supporting the restriction of the test method regarding the testing of solids.
Keywords
UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eyeCONsortium for in vitro Eye Irritation testing strategySLSDPBSSIRCOECDDRDFPRFNRCON4EISTEDMSOUN GHSOcular irritationtest guidelineDimethyl sulfoxideUnited Nations Globally Harmonized System of Classification and Labelling of ChemicalsOrganization for Economic Co-operation and Developmentsodium lauryl sulfatePersDulbecco's phosphate buffered salinePersistenceFalse positive rateFalse negative rateoptical densitycorneal opacitySolvent controlPositive controlCONJCat 1Cat 2
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Authors
E. Adriaens, J.A. Sr., B.R. Meyer, L.C. Blakeman, N. Alépée, P. Fochtman, R. Guest, H. Kandarova, S. Verstraelen, A.R. Van Rompay,