| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8553886 | Toxicology in Vitro | 2018 | 27 Pages |
Abstract
Despite the differences in ketamine N-demethylation in combination with diazepam and methadone, the effect is unlikely to be of clinical relevance because ketamine and the other drugs do not have a small therapeutic margin.
Keywords
maximum reaction velocityHNKCLMCyPHLMVmaxNADPHPORcytochrome P450 enzymesISTinternal standardELMCapillary electrophoresisstandard deviationMEDdrug-drug interactionsnorketamineMichaelis-Menten constantdiazepamSubstrate concentrationMetabolismMethadoneMedetomidineMETHuman Liver Microsomesnicotinamide adenine dinucleotide phosphatehydroxynorketamineIntrinsic clearanceKetamineClint
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Authors
Friederike A. Sandbaumhüter, Sara Vimercati, Wolfgang Thormann, Meike Mevissen,